Reduced numbers of switched memory B cells with high terminal differentiation potential in Down syndrome
نویسندگان
چکیده
منابع مشابه
Reduced numbers of switched memory B cells with high terminal differentiation potential in Down syndrome
Children with Down syndrome (DS) have increased susceptibility to infections and a high frequency of leukemia and autoimmune disorders, suggesting that immunodeficiency and immune dysfunction are integral parts of the syndrome. A reduction in B-cell numbers has been reported, associated with moderate immunodeficiency and normal immunoglobulin levels. Here, we compared B-cell populations of 19 c...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2014
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.201445049